Peer-reviewed journal articles

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries. National Institute for Health and Care Research Global Health Research Unit on Global Surgery. BJ Surg​ 2023 Apr 20;

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A systematic review on the efficacy of tranexamic acid in head and neck surgery. Warda Jamshaid, Maryam Jamshaid, Chris Coulson, Neil Sharma, Jameel Muzaffar, Hannah Nieto. Clin Otolaryngol. 2023 Apr 11.  

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Functional Laryngeal Assessment in Patients with Tracheostomy Following COVID-19 a Prospective Cohort Study. Dawson C, Nankivell P, Pracy JP, Capewell R, Wood M, Weblin J, Parekh D, Patel J, Skoretz SA, Sharma N. Dysphagia. 2023 Apr;38(2):657-666. doi: 10.1007/s00455-022-10496-4. Epub 2022 Jul 16. PMID: 35841455

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The potential interaction between medical treatment and radioiodine treatment success: A systematic review. Zannat R, Lee J, Muzaffar J, Read ML, Brookes K, Sharma N, Boelaert K, McCabe CJ, Nieto HR. Front Endocrinol (Lausanne). 2023 Jan 4;13:1061555.

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Management and outcomes of military penetrating neck injuries: An eleven-year retrospective case note review. Pickering C, Muzaffar J, Reid C, Zakaria B, Coulson C, Sharma  N, Breeze J. Injury. 2023 Jan;54(1):119-123. doi: 10.1016/j.injury.2022.11.034. Epub 2022 Nov 12. PMID: 36400629

Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries. NIHR Global Health Unit on Global Surgery; COVIDSurg Collaborative. Lancet. 2022 Nov 5;400(10363):1607-1617. doi: 10.1016/S0140-6736(22)01846-3. Epub 2022 Oct 31.

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An external validation of C-reactive protein reduction as a predictor of healing following laryngopharyngectomy. James TW, Edwards MJ, Nieto H, Mehanna H, Pracy P, Jennings C, Sharma N, Nankivell P. Clin Otolaryngol. 2022 Jul 28. Online ahead of print. PMID: 35899897

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Civilian Penetrating Neck Trauma at a Level I Trauma Centre: A Five-Year Retrospective Case Note Review. Zakaria B, Muzaffar J, Borsetto D, Fussey J, Kumar R, Evans K, Pickering C, Reid C, Coulson C, Orr L, Pracy P, Nankivell P, Sharma N. Clin Otolaryngol. 2022 Jan;47(1):44-51. PMID 34323008.

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SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study. COVIDSurg Collaborative; GlobalSurg Collaborative.Anaesthesia. 2022 Jan;77(1):28-39. PMID 34428858.

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Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic. STARSurg Collaborative and COVIDSurg Collaborative. Br J Surg. 2021 Dec 1;108(12):1448-1464. doi: 10.1093/bjs/znab336. PMID: 34871379 

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Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study. COVIDSurg Collaborative. BMJ Open. 2021 Nov 30;11(11):e050830. doi: 10.1136/bmjopen-2021-050830. PMID: 34848515

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Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score. COVIDSurg Collaborative. Br J Surg. 2021 Nov 11;108(11):1274-1292. doi: 10.1093/bjs/znab183. PMID: 34227657

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Recurrence of Papillary Thyroid Cancer: A Systematic Appraisal of Risk Factors. Nieto HR, Thornton CEM, Menezes A, Brookes K, Fletcher A, Alshahrani M, Sharma N, Boelaert K, Cazier JB, Mehanna H, Smith VE, Read ML, McCabe CJ. R J Clin Endo Med. In Press Nov 2021

Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery. COVIDSurg Collaborative BJS Open 2021 Nov 9;5(6):zrab112.doi: 10.1093/bjsopen/zrab112.

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Prognostic indicators in clinically node-negative malignant primary salivary tumours of the parotid: A multicentre experience. Fussey J, Tomasoni M, Tirelli G, Giordano L, Galli A, Colangeli R, Cazzador D, Tofanelli M, Da Mosto MC, Bianchini C, Pelucchi S, Ubayasiri K, Elsayed M, Long P, Saratziotis A, Hajiioannou J, Piazza C, Deganello A, Lombardi D, Nicolai P, Pracy P, Sharma N, Nankivell P, Borsetto D, Boscolo-Rizzo P. Oral Oncol. 2021 Nov 3;123:105577. doi: 10.1016/j.oraloncology.2021.105577. Online ahead of print.

A digital score of tumour-associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma. Shaban M, Ahmed Raza SE, Hassan M, Jamshed A, Mushtaq S, Loya A, Batis N, Brooks J, Nankivell P, Sharma N, Robinson M, Mehanna H, Khurram SA, Rajpoot N. J Pathol. 2021 Oct 26. doi: 10.1002/path.5819. Online ahead of print.

Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study. COVIDSurg Collaborative. Lancet Oncol. 2021 Nov;22(11):1507-1517. doi: 10.1016/S1470-2045(21)00493-9. Epub 2021 Oct 5.

Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study. COVIDSurg Collaborative; GlobalSurg Collaborative. Anaesthesia. 2021 Nov;76(11):1454-1464. doi: 10.1111/anae.15560. Epub 2021 Aug 9.

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Development and validation of an improved classification and risk stratification system for carotid body tumors: A multinational collaborative cohort study. Mehanna H, Mistry P, Golusinski P, Maio PD, Nankivell P, Snider F, Ferrante AMR, Montalto N, Nicolai P, Marcantoni A, Grandi C, Zavatta M, Grego F, Malec K, Hosal S, Suslu N, Kuscu O, Torrealba I, Valdes F, Sharma N, Ayuk J, Monksfield P, Irving R, Dunn JA, Kay M, Borsetto D. Head Neck. 2021 Aug 21. doi: 10.1002/hed.26844. Online ahead of print. PMID: 34418219

Remote triage incorporating symptom-based risk stratification for suspected head and neck cancer referrals: A prospective population-based study. Hardman JC, Tikka T, Paleri V; ENT UK, BAHNO and INTEGRATE (The UK ENT Trainee Research Network). Cancer. 2021 Aug 19. doi: 10.1002/cncr.33800. Online ahead of print. PMID: 34411287

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Lack of predictive tools for conventional and targeted cancer therapy: Barriers to biomarker development and clinical translation. Batis N, Brooks JM, Payne K, Sharma N, Nankivell P, Mehanna H. Adv Drug Deliv Rev. 2021 Jun 27:113854. doi: 10.1016/j.addr.2021.113854.

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study. COVIDSurg Collaborative, GlobalSurg Collaborative. Br J Surg. 2021 Mar 24:znab101. doi: 10.1093/bjs/znab101.

Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study. COVIDSurg Collaborative; GlobalSurg Collaborative. Anaesthesia. 2021 Jun;76(6):748-758. doi: 10.1111/anae.15458. Epub 2021 Mar 9.

Head and neck cancer surgery during the COVID-19 pandemic: An international, multicenter, observational cohort study. COVIDSurg Collaborative. Cancer. 2021 Jul 15;127(14):2476-2488. doi: 10.1002/cncr.33320. Epub 2020 Dec 21.

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Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic. COVIDSurg Collaborative. Br J Surg. 2021 Jan 27;108(1):88-96. PMID 33640908

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Dysphagia presentation and management following coronavirus disease 2019: an acute care tertiary centre experience. C Dawson, R Capewell, S Ellis, S Matthews, S Adamson, M Wood, L Fitch, K Reid, M Shaw, J Wheeler, P Pracy, P Nankivell, N Sharma. J Laryngol Otol. 2020 Nov 10:1-13

Outcomes from elective colorectal cancer surgery during the SARS‐CoV‐2 pandemic. COVIDSurg Collaborative. Colorectal Dis. 2020 Nov 15. doi: 10.1111/codi.15431. 

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Elective Cancer Surgery in COVID-19–Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study. Glasbey JC, Bhangu A, and on behalf of the COVIDSurg Collaborative. J Clin Oncol. 2020 Oct 6:JCO2001933. doi: 10.1200/JCO.20.01933

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Tracheostomy in COVID-19 - safety and 30-day outcomes of the first 100 cases from a single tertiary UK hospital: a prospective observational cohort study. Queen Elizabeth Hospital Birmingham COVID-19 airway team.  Br J Anaesth. 2020 Aug 28:S0007-0912(20)30678-4

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Delaying surgery for patients with a previous SARS-CoV-2 infection. COVIDSurg Collaborative. Br J Surg​ 2020 Sep 25. doi: 10.1002/bjs.12050.

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COVIDTrach; the outcomes of mechanically ventilated COVID-19 patients undergoing tracheostomy in the UK: Interim Report. COVIDTrach collaborative. Br J Surg 2020 Sep 17.

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Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study. COVIDSurg Collaborative. Lancet. 2020 Jul 4;396(10243):27-38.

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Conservative Management of Oesophageal Soft Food Bolus Impaction. Hardman J, Sharma N, Smith J, Nankivell P. Cochrane Database Syst Rev. 2020 May 11;5:CD007352. doi: 10.1002/14651858.CD007352.pub3.

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Definition of Locally Recurrent Head and Neck Squamous Cell Carcinoma: A Systematic Review and Proposal for the Odense-Birmingham Definition. Rohde M, Rosenberg T, Pareek M, Nankivell P, Sharma N, Mehanna H, Godballe C.  Eur Arch Otorhinolaryngol​. 2020 Jun;277(6):1593-1599.

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The Diagnostic Value of Cytology in Parotid Warthin's Tumors: International Multicenter Series. Borsetto D, Fussey JM, Cazzador D, Smith J, Ciorba A, Pelucchi S, Donà S, Boscolo-Rizzo P, Tomasoni M, Lombardi D, Nicolai P, Zanoletti E, Colangeli R, Emanuelli E, Osborne MS, Harrison K, Ahsan SF, Tofanelli M, Tirelli G, McNamara K, Liew L, Sharma N, Rao K, Pracy P, Nankivell P.  Head Neck. 2020 Mar;42(3):522-529. .

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Patient advocacy in head and neck cancer: Realities, challenges and the role of the multi-disciplinary team. Dawson C, Roe J, Starmer H, Brady G, Nund R, Coffey M, Govender R, Patterson JM, Nankivell P, Topping A, Sharma N, Parmar S, Elkington C, Merrit M, Stanbury D, Pracy P. Clin Otolaryngol. 2020 Jan 23.

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Prioritisation of research topics for head and neck cancer in Africa - Report of the International Collaboration On Improving Cancer outcomes in low and middle income countries - ICOnIC Africa. Sharma N, Fagan J, Wallace M, Joubert E, Greef L, Konney A, Simonds H, Vanderpuye V, Sewram V, Young T, Mehanna H; International Collaboration On Improving Cancer outcomes in low and middle income countries (ICOnIC Africa).  Oral Oncol. 2020 Mar;102:104503.

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Transoral tongue base mucosectomy for the identification of the primary site in the work-up of cancers of unknown origin: Systematic review and meta-analysis. Farooq S, Khandavilli S, Dretzke J, Moore D, Nankivell PC, Sharma N, et al. Oral oncology. 2019;91:97-106. Epub 2019/03/31.

Blunt neck trauma at a level I trauma centre: six-year retrospective case note review. Zakaria BA, Muzaffar J, Orr LE, Coulson CJ, Sharma N. The Journal of laryngology and otology. 2019:1-5. Epub 2019/10/15.

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Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial. Mehanna H, Robinson M, Hartley A, Kong A, Foran B, Fulton-Lieuw T, Dalby M, Mistry P, Sen M, O'Toole L, Al Booz H, Dyker K, Moleron R, Whitaker S, Brennan S, Cook A, Griffin M, Aynsley E, Rolles M, De Winton E, Chan A, Srinivasan D, Nixon I, Grumett J, Leemans CR, Buter J, Henderson J, Harrington K, McConkey C, Gray A, Dunn J; De-ESCALaTE HPV Trial Group. Lancet. 2019 Jan 5;393(10166):51-60.

Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma. Payne K, Spruce R, Beggs A, Sharma N, Kong A, Martin T, Parmar S, Praveen P, Nankivell P, Mehanna H. Head Neck. 2018 Jul;40(7):1598-1604. 

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The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review. Fussey JM, Bryant JL, Batis N, Spruce RJ, Hartley A, Good JS, McCabe CJ, Boelaert K, Sharma N*, Mehanna H*. Front Oncol. 2018 Apr 30;8:132. (joint senior author) 

ENT audit and research in the era of trainee collaboratives. Smith ME, Hardman J, Ellis M, Williams RJ; INTEGRATE (The National ENT Trainee Research Network). Eur Arch Otorhinolaryngol. 2018 Jul;275(7):1935-1938. 

Positive fresh frozen section margins as an adverse independent prognostic factor for local recurrence in oral cancer patients. Szewczyk M, Golusinski W, Pazdrowski J, Masternak M, Sharma N, Golusinski P. Laryngoscope. 2018 May;128(5):1093-1098

Epistaxis 2016: national audit of management. INTEGRATE (The National ENT Trainee Research Network). J Laryngol Otol. 2017 Dec;131(12):1131-1141. 

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The British Rhinological Society multidisciplinary consensus recommendations on the hospital management of epistaxis. INTEGRATE (The National ENT Trainee Research Network). J Laryngol Otol. 2017 Dec;131(12):1142-1156. 

Can trainees design and deliver a national audit of epistaxis management? A pilot of a secure web-based audit tool and research trainee collaboratives. Mehta N, Williams RJ, Smith ME, Hall A, Hardman JC, Cheung L, Ellis MP, Fussey JM, Lakhani R, McLaren O, Nankivell PC, Sharma N, Yeung W, Carrie S, Hopkins C. J Laryngol Otol. 2017 Jun;131(6):518-522. 

The effect of trainee research collaboratives in the UK. Nepogodiev D, Chapman SJ, Kolias AG, Fitzgerald JE, Lee M, Blencowe NS; National Surgical Research Collaborative. Lancet Gastroenterol Hepatol. 2017 Apr;2(4):247-248. 

Students' participation in collaborative research should be recognised. STARSurg Collaborative. Int J Surg. 2017 Mar;39:234-237. 

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Pro-invasive Effect of Proto-oncogene PBF Is Modulated by an Interaction with Cortactin. Watkins RJ, Imruetaicharoenchoke W, Read ML, Sharma N, Poole VL, Gentilin E, Bansal S, Bosseboeuf E, Fletcher R, Nieto HR, Mallick U, Hackshaw A, Mehanna H, Boelaert K, Smith VE, McCabe CJ. J Clin Endocrinol Metab. 2016 Dec;101(12):4551-4563.

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Multifocality in Sporadic Medullary Thyroid Carcinoma: An International Multicenter Study. Essig GF Jr, Porter K, Schneider D, Arpaia D, Lindsey SC, Busonero G, Fineberg D, Fruci B, Boelaert K, Smit JW, Meijer JA, Duntas LH, Sharma N, Costante G, Filetti S, Sippel RS, Biondi B, Topliss DJ, Pacini F, Maciel RM, Walz PC, Kloos RT. Thyroid. 2016 Nov;26(11):1563-1572.

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ENT Trainee Research Collaborative – West Midlands. National prospective cohort study of peritonsillar abscess management and outcomes: the Multicentre Audit of Quinsies study. J Laryngol Otol. 2016 Aug;130(8):768-76. 

The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer. Read ML, Seed RI, Modasia B, Kwan PP, Sharma N, Smith VE, Watkins RJ, Bansal S, Gagliano T, Stratford AL, Ismail T, Wakelam MJ, Kim DS, Ward ST, Boelaert K, Franklyn JA, Turnell AS, McCabe CJ. Mol Carcinog. 2016 Jan;55(1):15-26. 

Hardman JC, Smith JA, Nankivell P, Sharma N, Watkinson JC. Re-operative thyroid surgery: a 20-year prospective cohort study at a tertiary referral centre. Eur Arch Otorhinolaryngol. 2015 Jun;272(6):1503-8. 

The presentation, natural history and outcome of T1 a/b thyroid cancer with regard to new grading systems. Smith JA, Sharma N, Nankivell P, Watkinson JC. Eur Arch Otorhinolaryngol. 2015 Feb;272(2):439-44. 

The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells. Read ML, Seed RI, Fong JC, Modasia B, Ryan GA, Watkins RJ, Gagliano T, Smith VE, Stratford AL, Kwan PK, Sharma N, Dixon OM, Watkinson JC, Boelaert K, Franklyn JA, Turnell AS, McCabe CJ. Endocrinology. 2014 Apr;155(4):1222-34.

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Regulation of pituitary tumor transforming gene (PTTG) expression and phosphorylation in thyroid cells. Lewy GD, Ryan GA, Read ML, Fong JC, Poole V, Seed RI, Sharma N, Smith VE, Kwan PP, Stewart SL, Bacon A, Warfield A, Franklyn JA, McCabe CJ, Boelaert K. Endocrinology. 2013 Nov;154(11):4408-22.

Fine needle aspiration and medullary thyroid carcinoma: the risk of inadequate preoperative evaluation and initial surgery when relying upon FNAB cytology alone. Essig GF Jr, Porter K, Schneider D, Debora A, Lindsey SC, Busonero G, Fineberg D, Fruci B, Boelaert K, Smit JW, Meijer JA, Duntas L, Sharma N, Costante G, Filetti S, Sippel RS, Biondi B, Topliss DJ, Pacini F, Maciel RM, Walz PC, Kloos RT. Endocr Pract. 2013 Nov-Dec;19(6):920-7. 

Manipulation of PBF/PTTG1IP phosphorylation status; a potential new therapeutic strategy for improving radioiodine uptake in thyroid and other tumors. Sharma N*, Smith VE*, Watkins RJ, Read ML, Ryan GA, Kwan PP, Martin A, Watkinson JC, Boelaert K, Franklyn JA, McCabe CJ. J Clin Endocrinol Metab. 2013 Jul;98(7):2876-86. Joint first author 

Mining the proteome: the application of tandem mass spectrometry to endocrine cancer research. Sharma N, Martin A, McCabe CJ. Endocr Relat Cancer. 2012 Jul 22;19(4):R149-61. 

Proto-oncogene PBF/PTTG1IP regulates thyroid cell growth and represses radioiodide treatment. Read ML, Lewy GD, Fong JC, Sharma N, Seed RI, Smith VE, Gentilin E, Warfield A, Eggo MC, Knauf JA, Leadbeater WE, Watkinson JC, Franklyn JA, Boelaert K, McCabe CJ. Cancer Res. 2011 Oct 1;71(19):6153-64. 

Pituitary tumor transforming gene binding factor: a new gene in breast cancer. Watkins RJ, Read ML, Smith VE, Sharma N, Reynolds GM, Buckley L, Doig C, Campbell MJ, Lewy G, Eggo MC, Loubiere LS, Franklyn JA, Boelaert K, McCabe CJ. Cancer Res. 2010 May 1;70(9):3739-49.

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Hypopharyngeal perforation during endoscopic ultrasound treated by primary repair. Sharma N, Jindal M, Mahon B, Pracy P. Head Neck. 2011 May;33(5):756-8. 

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Intraoperative dilated pupil during nasal polypectomy. Jindal M, Sharma N, Parekh N. Eur Arch Otorhinolaryngol. 2009 Jul;266(7):1035-7.